Research Programs

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As the most common malignant pediatric brain tumour, medulloblastoma (MB) remains one of the leading causes of childhood cancer mortality with median survival dependent on molecular classification.

Medulloblastoma

Team Brain Medulloblastoma: (top row from left to right) Manoj Singh, Erika Apel, Laura Escudero, Yujin Suk, Hardik Patel, (bottom row from left to right) Petar Miletic, Arjun Chaudhary, Stefan Clusters, Sheila Singh, Chitra Venugopal, Dillon McKenna

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Glioblastoma (GBM) is the most aggressive adult brain cancer, with a 15-month median survivorship, attributed to the highly aggressive, treatment-refractory brain tumour initiating cell population.

Glioblastoma

Team Brain Medulloblastoma: (top row from left to right) Petar Miletic, Alisha Anand, Kui Zhai, Arush Puri (Alumnus), Tiegan Korman, Mo Taleb, Aapti Khanna, Vaseem Shaik, (bottom row from left to right) Manoj Singh, Max Topley, Will Maich, Sheila Singh, Chitra Venugopal, Shawn Chafe, Shan Grewal, Dillon McKenna

Catch a glimpse behind the scenes to how our research discoveries are made. In the laboratory, we work with tissue culture from animal models and patient samples, measuring outcomes and analyzing results using gold-standard molecular biology techniques in state-of-the-art facilities at the McMaster Stem Cell and Cancer Research Institute.

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Primary lung, breast and skin tumour often migrate to the brain, seeding brain metastases (BM), which hold a median survival time of only months in affected patients, despite current clinical modalities.

Brain Metastasis

Team Brain Medulloblastoma: (top row from left to right) Manoj Singh, Agata Kieliszek, Daniel Mobilio, Patrick Ang (Alumnus), (bottom row from left to right) Petar Miletic, Kui Zhai, Sheila Singh, Shawn Chafe, Chitra Venugopal, Dillon McKenna